货号

RABZ021

别名Alternative Name

IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53

应用

IHC-P

反应种属

Human

稀释比

IHC-1:100-1:200

SwissProt ID

P38398

宿主

Rabbit

偶联物

Unconjugated

修饰

Unmodified

基因 ID

672

基因名

BRCA1

亚型

IgG

克隆性

Monoclonal Antibody

克隆号

R04-8M-3

免疫原

A synthesized peptide derived from human BRCA1

研究领域

Epigenetics

背景信息

This  gene  encodes  a  190  kD  nuclear  phosphoprotein  that  plays  a  role  in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene  contains  22  exons  spanning  about  110  kb  of  DNA.  The encoded  protein combines  with  other  tumor  suppressors,  DNA  damage  sensors,  and  signal transducers to form a large multi-subunit protein complex known as the BRCA1- associated genome surveillance complex  (BASC).  This  gene  product  associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of  inherited  breast  and  ovarian  cancers.  Alternative  splicing  plays  a  role  in modulating the subcellular  localization  and  physiological  function  of  this  gene. Many  alternatively  spliced  transcript  variants,  some  of  which  are  disease- associated  mutations,  have  been  described  for  this  gene,  but  the  full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

纯化方式

Affinity Purified

形式

Liquid

存储缓冲液

Liquid  in  50mM  Tris-Glycine(pH  7.4),  0.15M  NaCl,  40%Glycerol,  0.01%  sodium azide and 0.05% BSA.

保存温度

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

纯化方式

Affinity Purified

形式

Liquid

存储缓冲液

Liquid  in  50mM  Tris-Glycine(pH  7.4),  0.15M  NaCl,  40%Glycerol,  0.01%  sodium azide and 0.05% BSA.

保存温度

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

IHC

1:100-1:200