货号

RABZ015

别名Alternative Name

AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein  kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase; mitogen-activated; 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .

应用

WB, ICC/IF, FC, IP

反应种属

Human, Mouse, Rat

稀释比

WB-1:500-1:1000; ICC/IF-1:100-1:200; FC-1:100-1:200; IP-1; 20-1:50

SwissProt ID

P45983

宿主

Rabbit

偶联物

Unconjugated

修饰

Unmodified

基因 ID

5599

基因名

MAPK8

亚型

IgG

克隆性

Monoclonal Antibody

克隆号

R08-6G2

分子量

Calculated MW: 48 kDa;  Observed MW: 46,54 kDa

免疫原                  

Recombinant protein of human JNK1

研究领域

Signal Transduction

背景信息

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases  act as an integration point for multiple biochemical signals, and are involved in a  wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c- mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

纯化方式

Affinity Purified

形式

Liquid

存储缓冲液

Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

保存温度

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

纯化方式

Affinity Purified

形式

Liquid

存储缓冲液

Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

保存温度

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

WB

1:500-1:1000

ICC/IF

1:100-1:200

FC

1:100-1:200

IP

1:20-1:50