Alternative Name

ATLD2 ;

cb16 ;

Cyclin ;

DNA polymerase delta auxiliary protein ;

etID36690.10 ;

fa28e03 ;

fb36g03 ;

HGCN8729 ;

MGC8367 ;

Mutagen-sensitive 209 protein ;

OTTHUMP00000030189 ;

OTTHUMP00000030190 ;

PCNA ;

Pcna/cyclin ;

PCNA_HUMAN ;

PCNAR ;

Polymerase delta accessory protein ;

Proliferating cell nuclear antigen ;

wu:fa28e03 ;

wu:fb36g03

Gene name

>>DNA replication;>>Base excision repair;>>Nucleotide excision repair;>>Mismatch repair;>>Cell cycle;>>Tight junction;>>Hepatitis B

Protein Name

PCNA

Organism

Gene ID

UniProt ID

Human

5111

P12004

Mouse

P17918

Rat

P04961

Cellular Localization

Nucleus

Tissue specificity

Tonsil/ Colon

Function

Disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,Function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-20°C

IHC:

1:200-1000

WB:

1:500-5000

IF:

1:200-1000

ELISA

1:5000-20000

IP:

1:50-200