Alternative Name

VDAC1 ;

VDAC ;

Voltage-dependent anion-selective channel protein 1 ;

VDAC-1 ;

hVDAC1 ;

Outer mitochondrial membrane protein porin 1 ;

Plasmalemmal porin ;

Porin 31HL ;

Porin 31HM

Gene name

VDAC1

Protein Name

Voltage-dependent anion-selective channel protein 1

Organism

Gene ID

UniProt ID

Human

7416

P21796

Mouse

22333

Q60932

Rat

83529

Q9Z2L0

Cellular Localization

Cytoplasm, Membrane

Tissue specificity

Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in heart, liver and skeletal muscle (PubMed:8420959).

Function

Domain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.,Function:Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,similarity:Belongs to the eukaryotic mitochondrial porin family.,subunit:Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein.,tissue specificity:Heart, liver and skeletal muscle.Cytoplasm, Membrane

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein A

储存

-20°C

IHC:

1:200-1000

WB:

1:500-5000

IF:

1:200-1000

ELISA

1:5000-20000

IP:

1:50-200