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Gene name |
PIK3R3 |
|
Alternative Names |
GRB1; P85A; PI3-kinase p85-alpha subunit; PI3K; PI3K p85-alpha; P55G; PI3-kinase p85-gamma subunit; PI3K p85-gamma |
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UniProt ID |
|
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Background |
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. |
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